Mitochondrial dysfunction is implicated in dozens of age- related diseases, including Alzheimer's, retinal disease, liver dysfunction, immune senescence, and more. Mitrix Bio has pioneered a new way of addressing these diseases, using young bioreactor-grown mitochondria encased in vesicles, which we call "Mitlets." Our mission: prototype the components and techniques needed for a fundamental advancement in human medicine. |
The bioreactor grows young mitochondria in large quantities then wraps them in a special coating with receptors to target specific organs. The goal is to produce bioreactor-grown mitochondria on an industrial scale, sufficient to supplement every person over the age of 55... Learn more.
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Researchers in the past decade have found that mitochondria don't just sit in cells, but in fact are constantly transferred around the body, hundreds of billions in the bloodstream, brain, heart, and other organs, supplementing cells in need. Many of these mobile mitochondria are encased in extracellular vesicles - what we term "Mitlets"... Learn more.
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There are now many different techniques for transplanting mitochondria: between tissues in the body, or from a donor (family member for example) and patient. Cells readily "absorb" transplanted mitochondria and put them to use inside the cell. Since mitochondria require a lot of energy to make, this conveys significant evolutionary and survival advantage. At Mitrix we have tested transplantation, with excellent and predictable results, in the immune system, retina, brain, and skin. Learn more.
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We start life with a large inventory of healthy mitochondrial DNA, but over time, as our mitochondria replicate, these DNA start to accrue errors. The body has quality control strategies, but eventually the degeneration causes significant energy decline inside cells.... Learn more.
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Not only do mitochondria transfer naturally throughout the body, but this process seems intelligently controlled. Our new theory, called The Mitochondrial Cycle of the Body, proposes that the human body has large reservoirs of young mitochondria in the bone marrow or other areas, which are slowly rationed to peripheral tissues over time.... Learn more.
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The study of "Cellular Energetics" is a novel, valuable way to understand disease states and drug translation in older patients.... Learn more.
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To manage a mitochondrial aging platform, it makes sense to have a measurement tool to accurately measure the degeneration of mitochondrial DNA in the body... Learn more.
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To distribute supplies of scarce, valuable mitochondria for transplantation, society will need a mitochondrial banking system, analogous to blood banks or organ banks... Learn more.
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